The San Francisco 49ers are on the road to Caesars Superdome to take on the New Orleans Saints for their week 2 game. The game is scheduled to start 1:00 p.m. ET, airing on FOX.
The Saints are coming off a loss, whereas the 49ers are coming off a win, looking at their Week 1 performances. The 49ers narrowly won over their divisional opponents, the Seattle Seahawks, while the Saints lost the game by a single touchdown.
| Recommended Bets | FanDuel | BetMGM |
|---|---|---|
| Alvin Kamara to score a TD anytime during the game | +450 | +550 |
| Spencer Rattler to rush for Under 16.5 yards | -114 | -118 |
| Total Touchdowns Under 4.5 | -122 | -140 |
Alvin Kamara is a strong bet to score an anytime TD against the 49ers because he rushed for a TD in Week 1, reinforcing his role as the Saints’ red-zone workhorse. The 49ers are struggling with a lot of injuries and uncertainties, due to which we expect Kamara to go off in this Week 2 action.
As a pocket passer in New Orleans’ scheme, Rattler is considered a dual-threat quarterback and in Week 1 he had 29 rushing yards on four carries. However, the 49ers’ run defense could limit his mobility. With a pass-heavy focus of the Saints, we do not expect Rattler to go above 16.5 yards this time around.
The Saints vs 49ers game is likely to stay under 4.5 total touchdowns due to the 49ers’ injury-riddled roster, which may hamper their offensive firepower. With Brock Purdy out for the game, while TE George Kittle and OT Trent Williams listed as questionable, the 49ers’ red-zone efficiency may not be as effective. The Saints in Week 1 played well, but their lack of offensive firepower which kept them at 13 points, makes us believe that this will be a low scoring game.
The San Francisco 49ers (1-0) travel to face the New Orleans Saints (0-1) in Week 2, at Caesars Superdome. After a gritty 17-13 road win over the Seahawks, the 49ers battle injuries, with QB Brock Purdy and TE George Kittling out for the game, forcing Mac Jones to start.
Meanwhile, the Saints, stung by a 20-13 home loss to the Cardinals, rely on NFL sophomore QB Spencer Rattle. The Saints are still trying to recover from the loss of veteran QB Derek Carr, who decided to retire from the NFL earlier in 2025.
While the 49ers are supposed to be the far superior team in this matchup, all the injuries that they have suffered could make this game a very close contest.
Here are over/under and best player bets for the San Francisco 49ers according to BetMGM
| Over/ Under Bets | Over | Under |
|---|---|---|
| Mac Jones Passing Yards | 199.5 (-115) | 199.5 (-115) |
| Ricky Pearsall Receiving Yards | 53.5 (-140) | 53.5 (+105) |
| Mac Jones Longest Rush | 7.5 (-105) | 7.5 (-125) |
Below are some of the best player bets for the San Francisco 49ers according to BetMGM
Here are over/under and best player bets for the New Orleans Saints, according to BetMGM
| Over/ Under Bets | Over | Under |
|---|---|---|
| Spencer Rattler Passing Yards | 205.5 (-115) | 205.5 (-115) |
| Alvin Kamara Rushing Yards | 48.5 (-115) | 48.5 (-115) |
| Chris Olave Receiving Yards | 53.5 (-140) | 53.5 (+105) |
Below are some of the best player bets for the New Orleans Saints, according to BetMGM
The 49ers are predicted to defeat the Saints in Week 2. Despite injuries to QB Brock Purdy, George Kittle, and uncertainties revolving around Christian McCaffrey’s status, the 49ers are still somehow a very talented team. While nothing can be guaranteed, and both teams played decent in their Week 1 matchups, we expect the 49ers to takedown the Saints but not without a fight.
Until the Saints’s QB completely adjusts in his starting role for the team, we cannot fully trust them yet. Spencer Rattler had 214 yards with no touchdowns in Week 1 against the Cardinals, and going against the 49ers, their defense is even better than what the Cardinals had in store for him.
Prediction: 49ers to win the game by a narrow margin
The spread and the moneyline indicated that the 49ers should defeat the Saints according to BetMGM
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| 49ers | -3 (-110) | 40.5 (-110) | -165 |
| Saints | +3 (-110) | 40.5 (-110) | +140 |
(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)
When and where is the 49ers vs Saints game in Week 2?
The San Francisco 49ers face the New Orleans Saints on September 14, 2025, at Caesars Superdome, New Orleans.
What are the BetMGM betting odds for the 49ers vs Saints game?
49ers are 3-point favorites with a moneyline of 49ers (-165) and Saints (+140).
Name some key player prop bets for the game from BetMGM
Alvin Kamara Anytime TD: +550
Mac Jones Under 7.5 Longest Rush: -125
Ricky Pearsall Anytime TD: +210
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