The Bills vs Ravens is has the highest over-under for week 1
Regular season football in the NFL makes its much awaited comeback this week with the season opener between the Philadelphia Eagles and the Dallas Cowboys taking place on Thursday night.
While we begin the new season with a bang, featuring an enthralling rivalry game between two NFC East giants, week 1 has plenty more in store with games held across 4 days and 2 continents.
Yes, that’s right, the league’s first international game will also be held in Week 1 of the 2025-26 NFL season with the Kansas City Chiefs taking on the Los Angeles Chargers on Friday, September 5, in Sao Paulo, Brazil.
The final game of the week will see the Minnesota Vikings going up against Caleb Williams and the Chicago Bears, and while all these games can offer something spectacular, the game of the week is the one between the AFC juggernauts, the Buffalo Bills and the Baltimore Ravens.
Week 1 of the 2025-26 NFL season will feature 4 prime-time games, starting with the season opener in Philadelphia, where the Eagles take on the Cowboys on Thursday, September 4. The second prime-time game will be held the following day as the Chiefs and Chargers battle it out in Sao Paulo.
Then we will have Sunday Night Football (SNF) and Monday Night Football (MNF) games to close out the week with the Ravens taking on the Bills, and the Vikings up against the Bears, respectively.
| Day and Date | Matchup | Time (ET) | Broadcast Partners |
|---|---|---|---|
| Thursday, September 4 | Dallas Cowboys @ Philadelphia Eagles | 8:20 PM | NBC, Peacock |
| Friday, September 5 | Kansas City Chiefs @ Los Angeles Chargers | 8:00 PM | YouTube, NFL+ |
| Sunday, September 7 | Baltimore Ravens @ Buffalo Bills | 8:20 PM | NBC, Peacock |
| Monday, September 8 | Minnesota Vikings @ Chicago Bears | 8:15 PM | ABC, ESPN, NFL+ |
Looking at the spread for all 16 week 1 matchups, only the Eagles are just one of two teams to be favored by more than a touchdown as per the odds on FanDuel. Philadelphia is the favorite in its week 1 matchup against the Cowboys by 7.5 points. The same is true for the Denver Broncos, who are favored by 7.5 points over the Tennessee Titans.
As for the highest over-under, that goes to the Bills and Ravens game, which is set at 52.5 points. This is the only matchup with an over-under above 50 points. The Steelers against the Jets game sees the lowest over-under at 37.5.
With that, let us now take a look at the betting odds as per FanDuel for all week 1 matchups, along with the predictions.
The Philadelphia Eagles come in as the reigning Super Bowl Champions and the favorites to win this match.
Moneyline: Eagles -400, Cowboys +315
Spread: Eagles -7.5 (-110), Cowboys +7.5 (-110)
Total: 47.5 (Over -110, Under -110)
Prediction: Philadelphia’s superior roster gets the better of Dallas – Eagles win.
The Kansas City Chiefs have owned the AFC West for nearly a decade, and until the others can stop them, they still remain the team to beat.
Moneyline: Chiefs -168, Chargers +140
Spread: Chiefs -3 (-114), Chargers +3 (-106)
Total: 45.5 (Over -112, Under -108)
Prediction: Could be a close one, but we give a slight edge to Kansas City – Chiefs win
The Indianapolis Colts are week 1 favorites over the Miami Dolphins.
Moneyline: Colts -116, Dolphins -102
Spread: Colts -1.5 (-104), Dolphins +1.5 (-118)
Total: 46.5 (Over -120, Under -102)
Prediction: Miami’s high-flying offense leads to a Dolphins win
The Steelers made plenty of moves this offseason. Aaron Rodgers and DK Metcalf provide a fresh new offense, while their top-notch defense makes them the favorites in this matchup.
Moneyline: Steelers -144, Jets +122
Spread: Steelers -2.5 (-115), Jets +2.5 (-105)
Total: 37.5 (Over -115, Under -105)
Prediction: Steelers defense stops the Jets from scoring big – Pittsburgh wins
The Jaguars enter their week 1 matchup as the favorites over the Panthers.
Moneyline: Jaguars -158, Panthers +134
Spread: Jaguars -3 (-110), Panthers +3 (-110)
Total: 46.5 (Over -118, Under -104)
Prediction: Carolina can pull off an upset if Bryce Young continues building from last year – Panthers win
The Arizona Cardinals come into this week 1 matchup as the favorites.
Moneyline: Cardinals -270, Saints +220
Spread: Cardinals -5.5 (-120), Saints +5.5 (-102)
Total: 42.5 (Over -105, Under -115)
Prediction: Saints’ problems under center could be a problem – Cardinals win
The Commanders went to the NFC Conference Championship game last season, while the Giants were one of the worst teams in the league. But New York has had a decent offseason.
Moneyline: Commanders -260, Giants +215
Spread: Commanders -6.5 (-104), Giants +6.5 (-118)
Total: 45.5 (Over -112, Under -108)
Prediction: Washington’s offense should put up sufficient points despite a strong Giants’ defensive front – Commanders win
This NFC South rivalry matchup has the Buccaneers as the favorites over the Falcons.
Moneyline: Buccaneers -134, Falcons +114
Spread: Buccaneers -2.5 (-105), Falcons +2.5 (-115)
Total: 46.5 (Over -110, Under -110)
Prediction: Tampa Bay is the stronger team between the two – Buccaneers win
The Bengals head into this AFC North rivalry game as the favorites over the Browns.
Moneyline: Bengals -225, Browns +188
Spread: Bengals -5.5 (-105), Browns +5.5 (-115)
Total: 47.5 (Over -110, Under -110)
Prediction: All pieces are in place for the Bengals – Cincinnati wins
The New England Patriots enter the game as the favorites.
Moneyline: Patriots -144, Raiders +122
Spread: Patriots -2.5 (-118), Raiders +2.5 (-104)
Total: 43.5 (Over -120, Under -102)
Prediction: New England wins a close game
An NFC West matchup has the 49ers as the favorites against the Seahawks in week 1.
Moneyline: 49ers -136, Seahawks +116
Spread: 49ers -2.5 (-110), Seahawks +2.5 (-110)
Total: 44.5 (Over -110, Under -110)
Prediction: Seahawks offseason transactions may have boosted the team, while the 49ers are suffering from a lack of quality receivers – Seahawks win
The Denver Broncos are heavy favorites in their week 1 matchup against the Tennessee Titans.
Moneyline: Broncos -420, Titans +330
Spread: Broncos -7.5 (-105), Titans +7.5 (-115)
Total: 42.5 (Over -110, Under -110)
Prediction: Despite having the number one overall pick in Cam Ward, the Titans will still find it tough against this Broncos team – Denver wins
This exciting NFC North showdown between the Packers and Lions has the former as the favorites at home.
Moneyline: Packers -142, Lions +120
Spread: Packers -2.5 (-112), Lions +2.5 (-108)
Total: 47.5 (Over -102, Under -120)
Prediction: Lions edge out the Packers in a thriller – Detroit wins
The Houston Texans enter this week 1 matchup as the underdogs against the Los Angeles Rams.
Moneyline: Rams -142, Texans +120
Spread: Rams -2.5 (-118), Texans +2.5 (-104)
Total: 44.5 (Over -105, Under -115)
Prediction: In a game that could go to the end, we predict the Rams to edge out the Texans.
The Ravens and Bills are evenly matched in this week 1 encounter.
Moneyline: Ravens -108, Bills -108
Spread: Ravens +1.5 (-122), Bills -1.5 (+100)
Total: 50.5 (Over -115, Under -105)
Prediction: Last year’s divisional matchup is tough to call, but we predict revenge for the Ravens – Baltimore wins.
The Bears are the underdogs at home to the Minnesota Vikings in this NFC North rivalry game.
Moneyline: Vikings -132, Bears +112
Spread: Vikings -1.5 (-115), Bears +1.5 (-105)
Total: 43.5 (Over -105, Under -115)
Prediction: We go with the underdog Bears to win against the Vikings.
All of the above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!
Mandatory Credit: Bill Streicher-Imagn Images
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