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Kansas City Chiefs vs Philadelphia Eagles Preview, Predictions, and Betting Odds – NFL 2025-26 Season Week 2

Eric Divakaran
American Football / NFL
14/09/2025 – 21:25
Kansas City Chiefs
VS
21:25
14/09/2025
Philadelphia Eagles
Odds updated on September 11, 2025 at 12:09 am

Kansas City Chiefs vs Philadelphia Eagles Preview, Predictions, and Betting Odds – NFL 2025-26 Season Week 2

The Kansas City Chiefs are set to take on the Philadelphia Eagles on September 14, 2025, at GEHA Field in a high anticipated rematch of Super Bowl LIX. The Eagles, 1-0 after a 24-20 Week 1 win over the Cowboys, seek to build on their Super Bowl domination, with Jalen Hurts and Saquon Barkley leading a potent offense.

Meanwhile, Chiefs still stinging from their 0-1 start with a 27-21 loss to the Chargers in Brazil, crave revenge with Patrick Mahomes and Travis Kelce leading the way.

This NFL-AFC clash brings together two dynasties against each other, with the Chiefs’ home-field advantage clashing against Philly’s defensive superpowers. This matchup is a must watch for all the football fans across the world, as it does not get bigger than this.

Recommended BetsFanDuelBetMGM
Total Score (Under 50.5)-186-165
Kansas City Chiefs to cover the +2.5 spread-138-140
Eagles to win the game-110-115

Analysis and Rationale

The Eagles vs Chiefs Week 2 total of under 50.5 is favored due to both teams’ Week 1 offensive rust. Eagles’ scored just 24 points vs Cowboys, while the Chiefs lost the game against the Chargers with Mahomes getting sacked twice and players dropping essential catches. Add the fact that the Chiefs are missing multiple offensive weapons from their team, we assume that under 50.5 scoreline is a safe bet.

For the second bet, the Chiefs are likely to cover the +2.5 spread against the Eagles, due to their home-field advantage at Arrowhead Stadium and Patrick Mahomes’ record as an underdog. Despite a Week 1 loss, the Chiefs’ offense may exploit Eagles’ defense, who were disappointing in their last game.

Lastly, the Eagles are the favorite to win the game simply because they have the better talent offensively and defensively. As mentioned earlier, the Chiefs are missing key players including Xavier Worthy and Rashee Rice, which is not going to help their case. With Travis Kelce not looking like the TE we know about, we doubt the Chiefs’ chances to win the game.

Kansas City Chiefs vs Philadelphia Eagles Preview

The rematch of the Super Bowl LIX between the Chiefs vs Eagles will be nothing short of electric. The Eagles completely outclassed the Chiefs in Super Bowl LIX, and this was only the second time we’ve seen Mahomes, Andy Reid, and the Chiefs look helpless in the biggest stage.

The Eagles and Jalen Hurts won their first Super Bowl trophy and are trying to win two in a row. And there is no better test than playing the best of the best in the AFC. While the Eagles won the first game of their season opener, it wasn’t what everybody expected. The Cowboys gave them a run for their money and simply put, the Eagles just didn’t look as hungry as they did in the Super Bowl.

While the Eagles are the favorites to win the matchup, the Chiefs are still the Chiefs, meaning that they still have the winningest coach and best quarterback of this decade.

Kansas City Chiefs Best Bets – Over/Under and Player Bets

Here are over/under and best player bets for the Kansas City Chiefs, according to BetMGM

Over/Under BetsOverUnder
Patrick Mahomes Passing Yards247.5 (-115)247.5 (-115)
Marquise Brown 57.5 (-118)57.5 (-110)
Isiah Pacheco 35.5 (-110)35.5 (-118)

Kansas City Chiefs Best Player Bets

Below are some of the best player bets for the Kansas City Chiefs, according to BetMGM

  • Patrick Mahomes to throw under 0.5 interceptions thrown: -125
  • Isiah Pacheco to rush for under 35.5 rushing yards: -118
  • Travis Kelce to receive over 49.5 yards: -118

Philadelphia Eagles Best Bets – Over/Under and Player Bets

Here are over/under bets for the Philadelphia Eagles according to BetMGM

Over/Under BetsOverUnder
Jalen Hurts Passing Yards203.5 (-115)203.5 (-115)
Saquon Barkley Rushing Yards87.5 (-115)87.5 (-115)
A.J. Brown Receiving Yards63.5 (-115)63.5 (-115)

Philadelphia Eagles Best Player Bets

Below are some of the best player bets for the Philadelphia Eagles, according to BetMGM

  • Jalen Hurts to throw under 0.5 interceptions: -200
  • Dallas Goedert to have under 4.5 receptions made: -160
  • Jalen Hurts to rush for under 43.5 rushing yards: -118
  • Saquon Barkley to have under 19.5 longest rushing yards: -118

Eagles vs Chiefs Prediction for the 2025-26 Season

We predict that the Eagles will manage to win this contest against the Kansas City Chiefs and the reason is simple; lack of personnel for the Chiefs. While the Chiefs are stout defensively, offensively they are missing their key receivers. And with Travis Kelce still trying to find his game, Mahomes will need more help than what he has currently.

While the Eagles looked rusty to start off their season, we believe that it’s only a matter of time before the Eagles get back to right where they were last season. Being dominant defensively, and having a very balanced offense in terms of rushing and passing with the football. The Eagles already beat the same group of Chiefs last season, and without Rashee Rice or Xavier Worthy, the Chiefs are in a horrible spot currently.

Expect a fight to be put up by the Chiefs but the Eagles to walk away with the win.

Prediction: Eagles win the game

Chiefs vs Eagles Betting Odds and Spread

The Eagles are the favorites to win this contest against the Chiefs, looking at the spread and moneyline, according to BetMGM.

TeamsSpreadTotalMoneyline
Eagles-1 (-105)47 (-110)-115
Chiefs+1 (-115)47 (-110)-105

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

When and where is the Chiefs vs Eagles game in Week 2?

The Kansas City Chiefs host the Philadelphia Eagles on September 14, 2025, at GEHA Field at Arrowhead Stadium.

What are the BetMGM betting odds for the Chiefs vs Eagles game?

BetMGM lists the Eagles as 1-point favorite (-105), Chiefs +1 (-115), with a moneyline of Eagles -115, Chiefs -105.

What are key player prop bets for the game from BetMGM?

Mahomes Under 0.5 interceptions: -125
Barkley Under 19.5 Longest Rush: -118
Jalen Hurts Under 43.5 Rushing Yards: -118

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking. 

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